Chronic leukemia

This video talks about chronic leukemias. These leukemias have slightly more mature cells.

Chronic Lymphoid Leukemia (CLL)
The leukemia cells in this type of leukemia are very fragile. If you put a drop of blood on a microscope slide, the process of preparing it will make the CLL cells rupture. The ruptured cells are called smudge cells.

When the CLL cells leave the bone marrow, they are mature enough that they go to the places the regular type of that cell go. They go to the Lymph nodes, liver, and spleen.There will be enlarged lymph nodes in this leukemia, and you can guess it is filled with CLL cells.